Do you know what a transition is??
When talking to someone, you want to maintain a conversation. when you open, you want to change to a different topic. the transition allows you to do that. If you stick to opening topic it will die out, and there will be silence and it will seem awkward.
In any interaction with women, you always want to be escalating (therefore you are leading the interaction). By changing conversation topics, you are leading the conversation. By moving topics to a more personal nature, you are escalating verbally.
1) From her answer, you can use her hooks (what topics or themes she mentions). This you use to start a new conversation.
2) Another one you can use is a cold read. check the net for these, not hard to find. they are just general observations which are very likely true
3) You can switch to different topic, or even a story by saying "that reminds of ..."
you can use this even if opener is short (functional) or it is long (opinion).
4) If your opener is long winded (like mystery method openers), then you will talk for a bit about it, getting the girls to open up and invest more in the interaction. IF they do then you switch topics by offering a hook, if they are interested, they will ask about the hook.
For more on hooks check this out:
http://mypuajourney.freeforums.org/conversation-ideas-part-2-t395.html
5) you can also compliment her on her being a nice person and different to others for answering you question, then go off into telling her how rude some people are, or you could ask if she is a nurse cause she is so kind - in a teasing manner.
6) if you ask her a functional quesiont - what time is it? where is x? - you can tease her, by saying she got it wrong, and that some one else siad it was else where. you are basically disagreeing with her in a fun playful way. if she argues back, you dont argue, you agree. i.e. her: "no i am telling the truth" you: "yeah, i believe you" - in a sarcastic way. This takes a certain personality to pull off.
Just think about how you talk with your friends, how do you change topics?
there is a difference with talking to friends and people you dont know. With friends, you can let long pauses go on, and yet still be interacting. This occurs when you have rapport. With a new person you dont have that, as you started the interaction, you have to continue the conversation, so you cant wait for her to continue it.